NS-3-008 HCl ( —— )

Catalog No. M21935 CAS No. 1172854-54-4

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HNMR

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Product Name

NS-3-008 HCl
Note

Research use only, not for human use.
Brief Description

NS-3-008 HCl is a transcriptional G0/G1 switch 2 (G0s2) inhibitor( IC50 of 2.25 μM).Administration of NS-3-008 inhibited the expression of G0s2 in healthy mice liver.?
Description

NS-3-008 HCl is a transcriptional G0/G1 switch 2 (G0s2) inhibitor( IC50 of 2.25 μM).Administration of NS-3-008 inhibited the expression of G0s2 in healthy mice liver.?In contrast, administration of NS-3-008 did not affect the MBP in wild-type sham and 5/6Nx mice.?NS-3-008 as a novel G0s2 inhibitor and showed that administration of this inhibitor ameliorated renal dysfunction in wild-type 5/6Nx mice.
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

G0s2
Research Area

——
Indication

——

CAS Number

1172854-54-4
Formula Weight

269.81
Molecular Formula

C14H24ClN3
Purity

>98% (HPLC)
Solubility

DMSO:120 mg/ml(444.76 mM; Need ultrasonic);H2O : 125 mg/mL (463.29 mM; Need ultrasonic)
SMILES

Cl.CCCCCCNC(=N)NCc1ccccc1
Chemical Name

——

1.Matsunaga N, et al. Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease. EBioMedicine. 2016 Nov;13:262-273.

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