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NS-3-008 HCl

CAS No. 1172854-54-4

NS-3-008 HCl ( —— )

Catalog No. M21935 CAS No. 1172854-54-4

NS-3-008 HCl is a transcriptional G0/G1 switch 2 (G0s2) inhibitor( IC50 of 2.25 μM).Administration of NS-3-008 inhibited the expression of G0s2 in healthy mice liver.?

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    NS-3-008 HCl
  • Note
    Research use only, not for human use.
  • Brief Description
    NS-3-008 HCl is a transcriptional G0/G1 switch 2 (G0s2) inhibitor( IC50 of 2.25 μM).Administration of NS-3-008 inhibited the expression of G0s2 in healthy mice liver.?
  • Description
    NS-3-008 HCl is a transcriptional G0/G1 switch 2 (G0s2) inhibitor( IC50 of 2.25 μM).Administration of NS-3-008 inhibited the expression of G0s2 in healthy mice liver.?In contrast, administration of NS-3-008 did not affect the MBP in wild-type sham and 5/6Nx mice.?NS-3-008 as a novel G0s2 inhibitor and showed that administration of this inhibitor ameliorated renal dysfunction in wild-type 5/6Nx mice.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    G0s2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1172854-54-4
  • Formula Weight
    269.81
  • Molecular Formula
    C14H24ClN3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:120 mg/ml(444.76 mM; Need ultrasonic);H2O : 125 mg/mL (463.29 mM; Need ultrasonic)
  • SMILES
    Cl.CCCCCCNC(=N)NCc1ccccc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Matsunaga N, et al. Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease. EBioMedicine. 2016 Nov;13:262-273.
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